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The symptoms are hard to ignore: headaches, fatigue, nausea, dizziness, and sensitivity to light and sound
Human safety data is insufficient to make any definitive statement about long-term use, with no large-scale toxicology or long-term safety trials in humans performed as of this writing
The clinical value of most of the so far described Nrf2 activators however was rather limited, mostly due to undesired interactions of these electrophiles with other cellular targets
10.1016/j.ejmech.2015.04.040 91 PizzinoG.IrreraN.CucinottaM.PallioG.ManninoF.ArcoraciV.et al (2017)
Due to sperms abundance of membrane polyunsaturated fatty acids (PUFAs) and their own innate capacity to generate reactive oxygen species (ROS) (via abnormally shaped sperm morphology), human sperm are highly susceptible to oxidative stress (inflammation)
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